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Updated: Jan 10, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

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在拼接因子突变癌症中共享拼接异常的统一机制

Prajwal C Boddu, Rahul Roy, Stephen Hutter

    bioRxiv : the preprint server for biology
    |November 24, 2025
    PubMed
    概括

    与癌症相关的拼接因子突变引发了共享的DNA损伤反应,导致改变了激酶信号传递和在髓质性疾病中保留的常见内部程序. 这重新连接了拼接因子SRSF1的活动,影响了跨多种突变的替代拼接.

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