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Updated: Jan 10, 2026

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对预测癌症结果的单细胞基础模型的实证评估.

Haitham Elmarakeby1, Ahmed Roman1, Shreya Johri1

  • 1Dana Farber Cancer Institute, Boston, MA, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

对于单细胞RNA测序 (scRNA-seq) 的基础模型在癌症研究中表现有前途. 然而,当前的模型对预测患者结果的基线具有有限的优势,突出显示需要进一步开发.

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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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