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Updated: Jan 10, 2026

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
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Published on: August 31, 2021

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基因的3D核位置和细分是它们对机械束的反应的首要原因

Saleh Oshaghi1, Oda Hovet1, Andrea Halaburkova1

  • 1Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316 Oslo, Norway.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

细胞通过重组它们的3D基因组结构来适应机械力. 这种动态的基因组重组影响基因表达,使细胞适应并影响健康和疾病.

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Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation16:27

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Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
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