一种临床级的神经刺激植入物,用于对生理活动的层次控制
Moaad Benjaber1,2, Mayela Zamora1,2, Robert Toth1,2
1Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
介绍DyNeuMo-2c,这是一种用于生物电子神经刺激的新型植入物,可以根据生物节奏调整治疗. 该设备可实现个性化,时间受限的闭环刺激,以改善治疗结果.
科学领域:
- 生物电子医学 生物电子医学
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
背景情况:
- 生理过程表现出可预测的生物节奏,如昼夜和睡眠-觉醒周期.
- 这些节奏影响疾病症状,闭环治疗生物标志物和对神经刺激的反应.
- 目前的神经刺激装置缺乏适应这些动态生理状态的适应性.
研究的目的:
- 介绍DyNeuMo-2c,一种临床级植入物,用于自适应性闭环神经刺激.
- 为了证明该设备能够与生物节奏同步治疗算法的能力.
- 为了验证系统对个性化,时间制约的神经调节的潜力.
主要方法:
- 开发DyNeuMo-2c,一个闭环神经刺激器,具有灵活的日间时间配置.
- 慢性测量大脑活动和运动,以确定患者特定的时间型和生物标志物.
- 对帕金森病和的使用病例进行基准验证,随后在非人类灵长类动物模型中进行体内部署.
主要成果:
- 在DyneuMo-2c成功地在基板模型中提供了时间受约束的闭环疗法.
- 在体内研究表明,该设备能够调节非人类灵长类动物的警和行为.
- 刺激的日间时间依赖的适应被证明是与生理状态同步的关键.
结论:
- DyNeuMo-2c代表了生物电子植入物的新架构.
- 该设备提供了在慢性治疗环境中进行时间约定的神经刺激的概念证明.
- 将生物节奏纳入神经刺激算法对于优化治疗疗效至关重要.
更多相关视频
09:27A Method for Systematic Electrochemical and Electrophysiological Evaluation of Neural Recording Electrodes
Published on: March 3, 2014
13.8K
08:42The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice
Published on: July 26, 2024
1.7K
相关概念视频
Ligand-gated Ion Channels
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Neurochemical Transmission: Sites of Drug Action
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
Drug Delivery: Parenteral Route
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Pain
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
