极性网络中的细胞周期振荡通过形态遗传线索促进了状态切换
KangBo Ng1,2,3, Hadjar Sebaa1,4, Nisha Hirani1
1The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
在C. elegans的生殖线芽细胞体中,细胞周期的振荡是为了平衡稳定的细胞极性与对发育线索的敏感性. 这种动态系统在发育过程中确保了细胞的正确形状和功能.
科学领域:
- 发育生物学 发展生物学
- 细胞生物学 细胞生物学
- 遗传学 是一个遗传学.
背景情况:
- 细胞极性建立对于形态发生至关重要,需要稳定而又适应性的极性域.
- 细胞必须协调内部极性网络与外部发展线索.
研究的目的:
- 为了研究C. elegans生殖线芽细胞体如何平衡极性稳定性与对线索的响应性.
- 阐明细胞循环调节在动态极性建立中的作用.
主要方法:
- 在C. elegans中利用了光遗传和化学扰动.
- 分析了PAR极性网络与细胞循环激酶CDK-1之间的相互作用.
- 建模了时间变化的极化景观.
主要成果:
- 将 PAR 网络与 CDK-1 合起来,会在新生儿细胞中产生低反状态,从而促进极性切换.
- 线粒体进入时CDK-1活动的增加加强了不对称性,导致稳定的PAR域模式.
- 低CDK/低反状态对于新的极化和重定向至关重要.
结论:
- 细胞极性电路中的线性振荡动态优化了形态发生的极化.
- 时间控制平衡了细胞状态强度与信号诱导的切换灵敏度.
- 这种机制可能是发展网络的一般性.
相关概念视频
01:21Cell Polarization by Rho Proteins
3.5K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
3.5K
01:32Cytoskeletal Coordination in Cell Migration
5.4K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.4K
01:45Positive Regulator Molecules
133.9K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
133.9K
02:39Positive Regulator Molecules
6.4K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
6.4K
01:28The Cell Cycle Control System
5.2K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
5.2K
02:11The Cell Cycle Control System
13.9K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
13.9K