相关实验视频

Updated: Jan 10, 2026

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
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Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton

Published on: April 19, 2018

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在老化中的C. elegans生殖系中失去远近端GLP-1/Notch激活梯度

Rustelle Janse van Vuuren, Pier-Olivier Martel, Patrick Narbonne

    bioRxiv : the preprint server for biology
    |November 24, 2025
    PubMed
    概括

    这项研究表明,老化的C. elegans生殖系中失去了诺奇激活梯度. 这一发现影响了人们对衰老期间干细胞维护的理解.

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    Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans09:18

    Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

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    Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism12:38

    Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

    Published on: December 18, 2013

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    相关概念视频

    Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

    Role Of Notch Signalling In Intestinal Stem Cell Renewal

    Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
    Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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    Notch Signaling Pathway03:14

    Notch Signaling Pathway

    The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
    The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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