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Updated: Jan 10, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

19

走向In Situ DNA结合的全长p53四聚合物的动力学

Özlem Demir1,2, Emilia P Barros1,3, Rommie E Amaro4

  • 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

恢复瘤抑制剂p53的活性是一种有前途的癌症治疗方法. 这项研究模拟了全长的p53四分体,揭示了其DNA相互作用和动态,包括癌症突变.

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