Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Timing and Consequences on Behavior01:08

Timing and Consequences on Behavior

338
In operant conditioning, the timing of reinforcement is crucial. For animals like rats and cats, immediate reinforcement (within a few seconds) is much more effective than delayed reinforcement. For example, a food reward for a rat needs to follow within 30 seconds of pressing a bar to be effective. 
Humans, however, can respond to delayed reinforcers. We often make decisions between immediate small rewards and delayed larger rewards. This ability to delay gratification is a significant...
338
Time-Domain Interpretation of PD Control01:07

Time-Domain Interpretation of PD Control

355
Proportional-Derivative (PD) control is a widely used control method in various engineering systems to enhance stability and performance. In a system with only proportional control, common issues include high maximum overshoot and oscillation, observed in both the error signal and its rate of change. This behavior can be divided into three distinct phases: initial overshoot, subsequent undershoot, and gradual stabilization.
Consider the example of control of motor torque. Initially, a positive...
355
Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

3.7K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
3.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Gut bacterial Infection drives Parkinsonian pathology in LRRK2 G2019S Knock-in Mice.

bioRxiv : the preprint server for biology·2026
Same author

Loss of ASIC1A-dependent inhibitory neuron activity in basolateral amygdala is associated with increased CO <sub>2</sub> -evoked jumping.

bioRxiv : the preprint server for biology·2026
Same author

Automated device for permitting free movement during simultaneous photometry and electrophysiology in mice.

Nature methods·2026
Same author

Distinct activity in prefrontal projections promotes temporal control of action.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Exercise enhances hippocampal-cortical ripple interactions in the human brain.

Brain communications·2026
Same author

Timing, Movement, and Reward Contributions to Prefrontal and Striatal Ramping Activity.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jan 10, 2026

Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry CIS-FSCV to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine
06:40

Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry CIS-FSCV to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine

Published on: April 23, 2020

3.7K

腹部 tegmental 区域多巴胺控制时间变化.

Matthew A Weber, Kartik Sivakumar, Alexandra S Bova

    bioRxiv : the preprint server for biology
    |November 24, 2025
    PubMed
    概括
    此摘要是机器生成的。

    行动的精确性依赖于大脑机制,但这些机制尚不清楚. 这项研究表明,腹部体区域 (VTA) 多巴胺神经元刺激通过减少时间变化来提高计时精度,从而提供了对帕金森病 (PD) 认知症状的见解.

    更多相关视频

    Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
    09:54

    Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

    Published on: August 10, 2012

    26.4K
    Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
    08:49

    Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry

    Published on: January 12, 2012

    22.4K

    相关实验视频

    Last Updated: Jan 10, 2026

    Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry CIS-FSCV to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine
    06:40

    Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry CIS-FSCV to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine

    Published on: April 23, 2020

    3.7K
    Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
    09:54

    Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

    Published on: August 10, 2012

    26.4K
    Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
    08:49

    Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry

    Published on: January 12, 2012

    22.4K

    科学领域:

    • 神经科学是一个神经科学.
    • 认知科学 认知科学
    • 行为科学 行为科学

    背景情况:

    • 精确度对于成功的行为至关重要,但基本的大脑机制仍然不太了解.
    • 多巴胺基电路与运动控制和执行功能有关,但它们在行为精度,特别是时机中的作用尚未完全阐明.

    研究的目的:

    • 调查多巴胺电路,特别是腹膜区域 (VTA) 多巴胺神经元在控制动作定时的精度中的作用.
    • 探索时间变化,帕金森病 (PD) 认知缺陷和执行功能障碍之间的关系.
    • 阐明VTA多巴胺神经元在间隔时间的神经元活动模式及其对时间变化的影响.

    主要方法:

    • 利用了一个间隔计时范式,要求参与者产生运动反应来估计时间间隔.
    • 研究了帕金森病 (PD) 患者的时间变化.
    • 在动物模型中使用VTA多巴胺神经元的光遗传学操纵 (损伤和刺激).
    • 使用GCaMP6s纤维光度仪记录VTA多巴胺神经元活动在计时任务.

    主要成果:

    • 帕金森病患者表现出时间变化的增加,与认知缺陷和执行功能障碍相关.
    • 损伤VTA多巴胺神经元导致时间变异性增加.
    • 在时间间隔开始时的VTA多巴胺神经元活动预测了随后的时间变化.
    • 刺激VTA多巴胺神经元降低了时间变异性,提高了健康和多巴胺贫乏受试者的时间精度.

    结论:

    • 腹部体区域 (VTA) 的多巴胺神经元在调节动作时间的精确性方面发挥着至关重要的作用.
    • VTA多巴胺神经元活动模式与时间变化有关,为帕金森病等疾病的时间缺陷提供了潜在的机制.
    • 准VTA多巴胺神经元活动可能为改善时间缺陷和相关认知障碍提供治疗策略.