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Updated: Jan 10, 2026

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
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Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells

Published on: January 29, 2019

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鼠标T细胞中的OCA-B/Pou2af1表达促进PD-1阻断诱导的自身免疫力,但对于抗瘤免疫力是不可或缺的

Junhong Du, Asit K Manna, Erik P Hughes

    bioRxiv : the preprint server for biology
    |November 24, 2025
    PubMed
    概括

    在T细胞中准转录系调节器OCA-B可以预防自身免疫性糖尿病,包括由检查点阻塞疗法诱导的糖尿病. 抑制OCA-B还可以保持抗瘤免疫力,这表明治疗自身免疫的治疗窗口.

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