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Updated: Jan 10, 2026

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GlueFinder:一个数据驱动的框架,用于合理发现分子

Jeffrey Skolnick1, Bharath Srinivasan2,3,4,5, Hongyi Zhou1

  • 1Center for the Study of Systems Biology, Georgia Institute of Technology, 950 Atlantic Dr NW, Atlanta, GA 30332, USA.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

我们开发了GlueFinder,这是一个计算平台,用于发现能够实现向蛋白质降解的分子. 这种无偏见的方法扩大了E3结合酶和蛋白质标的范围,用于新的治疗策略.

关键词:
E3 结合酶的使用分子粘合剂是一种分子粘合剂.降解剂 降解剂是一种降解剂.诱导近距离的诱导近距离理性的设计理性的设计.

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