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Updated: Jan 10, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Published on: November 11, 2016

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表观遗传钟的生物学与技术可靠性以及对疾病预后和干预反应的影响

Raghav Sehgal, Daniel Borrus, John Gonzalez

    bioRxiv : the preprint server for biology
    |November 24, 2025
    PubMed
    概括

    生物可靠性对于DNA甲基化钟或表观遗传钟至关重要,以准确估计生物年龄. 许多钟表表现出不良的生物稳定性,尽管具有良好的技术可重复性,但限制了它们的临床使用. 基于PC的时钟,如PCGrimAge,显示出更好的可靠性.

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