一种特征综合征将细胞形态与酵母子家族的糖解联系在一起
Linda C Horianopoulos1,2, Christina M Chavez3,4, Antonis Rokas3,4
1Laboratory of Genetics, DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, Center for Genomic Science Innovation, J.F. Crow Institute for the Study of Evolution, University of Wisconsin-Madison, WI 53726, USA.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
酵母物种表现出相关的特征,葡萄糖吸收率 (GUR) 与细胞大小和基因组大小相关. 这项研究扩展了282种物种的发现,揭示了Saccharomycotina酵母菌中更广泛的代谢和基因组特征综合征.
科学领域:
- 进化生物学 进化生物学
- 酵母基因组学 酵母基因组学
- 代谢生态学代谢生态学
背景情况:
- 跨物种的共同变化的特征为进化中的权衡和约束提供了洞察力.
- 以前的研究表明,在11种酵母菌种中,葡萄糖吸收率 (GUR) 和细胞表面积与体积 (SA:V) 比率之间存在反向相关性.
研究的目的:
- 测试GUR-SA:V相关性在Saccharomycotina酵母亚族 (282个物种) 的概括性.
- 确定共享进化历史对GUR和SA:V.共同变异的贡献.
- 为了确定这一酵母群体中与GUR和SA:V共变的额外特征.
主要方法:
- 在282种酵母菌种中,分析细胞外酸化率 (ECAR) 作为GUR的代理.
- 遗传学回归模型来解释特征共变的进化史.
- 统计分析以确定ECAR,SA:V,基因组大小和生长率之间的显著相关性.
主要成果:
- 在Saccharomycotina亚族中证实了ECAR和SA:V之间的显著相关性.
- 增加样本大小揭示了ECAR与基因组大小和生长率的显著相关性.
- 这些发现扩展了之前的观察,并表明酵母菌中存在多特征综合征.
结论:
- 在更广泛的酵母物种中,GUR (ECAR) 和SA:V之间的相关性是强大的.
- 代谢,基因组和形态特征似乎相互关联,由酵母菌的特征综合征来控制.
- 进化历史在塑造这些在Saccharomycotina亚族中的共同变化的特征方面发挥着作用.
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