同步的路径集成重新校准,但在头部方向和CA1位置单元中具有不同的地标控制动态
Ravikrishnan P Jayakumar1,2,3, Yotaro Sueoka1,4, Marissa Ferreyros1
1Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, 21218, USA.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
空间导航重新校准路径集成增益在位置和头部方向细胞. 这种神经协调取决于行为,在导航过程中确保灵活的内部位置和方向感.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 计算神经科学是一种神经科学.
背景情况:
- 空间导航依赖于路径集成,使用自动运动线索更新内部位置感.
- 路径集成涉及一个增益因子,该因子将自我运动与认知地图上的位移联系起来.
- 这种收益是可适应的,重新校准以与外部环境线索保持一致.
研究的目的:
- 为了研究底层的神经机制路径集成获得重新校准.
- 检查位置单元和头部方向 (HD) 单元的协调重新校准.
- 为了确定行为对重新校准过程的影响.
主要方法:
- 在动物中同时记录位置细胞和头部方向 (HD) 细胞.
- 诱导自动运动和视觉反之间的持续冲突在移动和不移动时与头部扫描.
- 分析神经群体活动和相对于地标的场移动动态.
主要成果:
- 路径集成增益重新校准发生在相同的位置和HD细胞在前进运动.
- 在头部扫描时的运动静止期间,HD细胞没有表现出重新校准.
- 位置和HD细胞在重新校准过程中显示了相对于地标的不同场移动动态.
结论:
- 路径集成重新校准是整个导航电路的协调过程.
- 再校准依赖于行为,突出了神经反应的灵活性.
- 这些发现揭示了内部位置感和方向感之间强大而适应性强的合.
更多相关视频
09:59Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus
Published on: October 11, 2017
13.3K
09:33Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
Published on: November 15, 2024
1.9K
相关概念视频
One-Degree-of-Freedom System
1.0K
In mechanical engineering, one-degree-of-freedom systems form the basis of a wide range of electrical and mechanical components. Using these models, engineers can predict the behavior of various parts in a larger system, which gives them insight into how different forces interact with each other.
A one-degree-of-freedom system is defined by an independent variable that determines its state and behavior. One example of a one-degree-of-freedom system is a simple harmonic oscillator, such as a...
A one-degree-of-freedom system is defined by an independent variable that determines its state and behavior. One example of a one-degree-of-freedom system is a simple harmonic oscillator, such as a...
1.0K
Major Somatic Sensory Pathways
3.2K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
3.2K
Direct Motor Pathways
4.7K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
4.7K
