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相关概念视频

Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Centrosome Duplication02:25

Centrosome Duplication

The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
Centrosome Duplication02:25

Centrosome Duplication

The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...
Overview of the Reproductive System01:31

Overview of the Reproductive System

The reproductive system generates offspring, ensuring the survival of the species. In humans, the reproductive system is complex and involves a variety of organs and hormones that work together to ensure successful reproduction.
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...

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Updated: Jun 18, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
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空间近距离测序地图:生殖中心的发育动态

Huili Wang, Junjie Xia, Peer Mohamed Suhail Mujibur Rahman

    bioRxiv : the preprint server for biology
    |November 24, 2025
    PubMed
    概括

    空间近距离测序 (Sprox-seq) 揭示了人类组织中复杂的蛋白质相互作用和基因表达. 这种多原子方法绘制了分子相互作用的地图,为细胞状态和组织结构提供了新的见解.

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    科学领域:

    • 免疫学 免疫学 免疫学
    • 分子生物学分子生物学
    • 基因组学就是基因组学.

    背景情况:

    • 空间蛋白和相互作用分析对于理解细胞过程至关重要.
    • 目前的方法缺乏与空间信息同时测量蛋白质,蛋白质复合体和mRNA的能力.

    研究的目的:

    • 引入空间近距离测序 (Sprox-seq),一种新的多原子技术.
    • 在记录分子位置的同时同时测量蛋白质,蛋白质复合体和mRNA.
    • 分析人类桃体组织和生殖中心中的蛋白质相互作用和基因表达.

    主要方法:

    • 开发并应用了空间近距离测序 (Sprox-seq).
    • 在人类桃体组织中分析了32种蛋白质,528种蛋白质相互作用和数千种mRNA.
    • 绘制了蛋白质相互作用的地图,并将它们与RNA表达和组织架构相关联.

    主要成果:

    • Sprox-seq成功地绘制了蛋白质相互作用的地图,并重新总结了RNA定义的生殖中心架构.
    • 与RNA数据相比,在光区中发现了更高的蛋白质相互作用复杂性.
    • 根据蛋白质与RNA的相互作用确定了不同的B细胞成熟路径.
    • 连接空间丰富的蛋白质复合体与免疫调节和线性通路.
    • 捕获了由VLA-4-VCAM1.1.介导的特定B细胞-状树叶细胞相互作用.

    结论:

    • Sprox-seq为细胞状态和组织内的分子相互作用提供了强大的多模式视图.
    • 该技术为研究空间环境中的蛋白质和细胞相互作用提供了一个全面的工具.
    • 这些发现有助于更好地了解B细胞的发育,免疫调节和组织组织.