带血细胞在出生时的转录和甲基化特征与BPD发展有关
Qianli Liu1,2, Kathryn A Helmin1, Jeanette Bailey3
1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
预测支气管肺功能障碍 (BPD) 需要更好的生物标志物. 这项研究在带血中发现了明显的基因表达和DNA甲基化模式,这可能预测早产婴儿的BPD风险.
科学领域:
- 新生儿科学 新生儿科学
- 基因组学就是基因组学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 支气管肺功能障碍症 (BPD) 是极其早产婴儿的常见呼吸道并发症.
- 目前的BPD预测模型缺乏准确性,需要用于早期干预的新生物标志物.
- 识别有风险的婴儿对于及时有效的治疗策略至关重要.
研究的目的:
- 确定新的转录和表观遗传生物标志物,用于预测早产婴儿的支气管肺功能障碍症 (BPD).
- 研究基因表达,DNA甲基化和BPD发展之间的关联.
- 探索在出生时可测量的潜在生物标志物,用于早期BPD风险评估.
主要方法:
- 使用了来自西北大学带血生物库 (NUCord) 的冷带血样本.
- 执行并行转录概况 (基因表达) 和DNA甲基化概况.
- 分析了与BPD发展有关的差异表达基因 (DEG) 和甲基化特征.
主要成果:
- 已确定与BPD相关的差异表达基因 (DEGs),与NF-κB信号传递和免疫反应有关.
- 在BPD病例中发现了微RNA基因和与葡萄糖代谢相关的基因中破坏的DNA甲基化特征.
- 与对照人群相比,在患有BPD的婴儿中确认了不同的转录和表观遗传特征.
结论:
- BPD的发展与特定的转录组和表观遗传特征有关.
- 这些签名在出生时可测量,显示了作为BPD预测生物标志物的潜力.
- 通过这些生物标志物的早期鉴定,可以为处于风险的早产婴儿及时进行干预.
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