前和后轨道前皮层对以结果为导向的行为有着明显的贡献
Qingfang Liu1, Daria Porter2, Hadeel Damra2
1National Institute on Drug Abuse Intramural Research Program, Baltimore, 21224, MD, USA.
bioRxiv : the preprint server for biology
|November 24, 2025
概括
前侧轨道前皮层 (OFC) 支持学习刺激-结果关联,而后侧 OFC 则有助于推断目标导向行为的当前选项值.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 决策 决策 决策 决策
背景情况:
- 侧轨前皮层 (OFC) 对于根据不断变化的结果值来调整选择至关重要.
- 侧面OFC的截然不同的前后子区域具有不同的细胞架构和连接性,但它们在结果导向行为中的特定作用尚未完全理解.
研究的目的:
- 研究前 (aOFC) 和后 (pOFC) 侧面OFC对结果导向行为的差异性贡献.
- 要确定这些子区域是否支持不同的功能:学习刺激-结果关联与推断当前选项值.
主要方法:
- 利用跨磁刺激 (TMS) 选择性地破坏以pOFC和aOFC为中心的功能网络.
- 用48名参与者进行了为期两天的结果值任务.
- 在学习前 (1日) 或在结果值之前 (2日) 进行TMS,然后进行选择测试.
主要成果:
- 在值前 (第二天) 扰乱了pOFC网络,影响了以结果为导向的选择,这表明在推断当前选项价值方面发挥了作用.
- 在学习 (第1天) 之前破坏aOFC网络会影响后续的以结果为导向的选择,这表明在学习刺激-结果关联中发挥了作用.
结论:
- 前侧和后侧OFC在以结果为导向的行为中起着不同的作用.
- aOFC对于学习刺激-结果关联至关重要.
- 在做决定时,POFC对于推断期权的当前价值至关重要.
关键词:
适应性行为适应性行为.认知地图是一个认知地图.决策是做出决策的过程.值 值 值 值 是一种推理推论是指一个推理.轨道前皮层 (orbitofrontal cortex) 是一个脑皮层.以结果为导向的行为.奖励 奖励 奖励 奖励 奖励跨的磁性刺激变量自动编码器 变量自动编码器更多相关视频
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