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结构引导的三角类阿片类受体的全调节

Jesse I Mobbs1,2,3, M Deborah Nguyen1,3, Owindeep Deo1,3

  • 1Monash Institute of Pharmaceutical Sciences, Parkville, Australia.

bioRxiv : the preprint server for biology
|November 24, 2025
PubMed
概括

研究人员使用冷EM发现了delta-opioid受体 (δOR) 上的一个新的结合部位. 这一发现使得能够开发出更安全的止痛药,通过积极的全调节剂 (PAMs) 向 δOR.

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