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低分子量肝素与产后阿司匹林 (LEAP):一个单中心试点随机对照试验

Evangelia Vlachodimitropoulou^1,2, Kinga Malinowski^1,2, Eric Kaplovitch³

¹Department of Fetal Medicine, Mount Sinai Hospital, Toronto, ON, Canada.

Blood vessels, thrombosis & hemostasis

|November 24, 2025

概括

一项试点研究发现,使用低分子量肝素 (LMWH) 和阿司匹林可实现更短的产后静脉血栓栓塞 (VTE) 预防. 与传统的LMWH治疗相比,这种方法可能会改善患者的生活质量.

科学领域:

产科和妇科产科和妇科
血液学血液学血液学
临床试验临床试验

背景情况:

对于高风险患者,建议使用低分子量肝素 (LMWH) 进行延长产后预防静脉血栓栓塞 (VTE),但对6周持续时间的证据有限.
评估替代性,可能更短的预防方案对于优化患者护理和坚持治疗至关重要.

研究的目的:

评估随机对照试验 (RCT) 的可行性,将6周的LMWH与3周的LMWH进行比较,然后为产后VTE预防使用3周的阿司匹林治疗方案.
评估高风险人群中招生,坚持,保留,安全和患者报告的结果.

主要方法:

一个单一中心的试点可行性研究随机选择了先前有VTE或高风险血栓友的患者.
参与者接受了6周的LMWH或3周的LMWH疗程以及3周的低剂量阿司匹林.
结果包括VTE事件,出血,患者满意度,入学率和坚持率.

主要成果:

该研究成功招募了30名参与者,他们的同意和坚持率很高 (96.5%的LMWH,93.9%的LMWH-阿司匹林).
没有发生VTE事件或产妇死亡;报告了一例延迟产后出血.
在产后6周的联合LMWH-阿司匹林组中,生活质量显著改善.

结论:

一个更大的RCT调查混合LMWH和阿司匹林治疗方案与标准LMWH用于产后VTE预防是可行的.
较短的组合疗法似乎是安全的,并可能提高患者的生活质量,因此需要进一步调查.

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