朱子生提取物通过PI3K/AKT通路抑制气道炎症改善感冒引起的喘
Xueqing Wang1, Xiaoxiong Song2, Haokang Ding2
1Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine Nanjing University of Chinese Medicine Nanjing China.
Food science & nutrition
|November 24, 2025
概括
朱子生提取物 (JGAE) 通过减少炎症和调节PI3K/Akt通路,有效治疗感冒引起的喘 (CA). 甘醇被确定为这个有前途的饮食干预中的关键活性成分.
科学领域:
- 药理学和传统医学的医学.
- 呼吸系统医学 呼吸系统医学
- 生物化学 生物化学
背景情况:
- 俊生 (JG) 是一种新的加工生产品,具有尚未开发的治疗潜力.
- 感冒引起的喘 (CA) 是一种呼吸系统疾病,需要有效的管理策略.
- 了解JG的生物活性成分和机制对于其在CA中的应用至关重要.
研究的目的:
- 调查生水溶性提取物 (JGAE) 对感冒引起的喘 (CA) 的保护作用.
- 确定关键的生物活性成分并阐明CA中JGAE的治疗机制.
- 为了比较JGAE与传统的干 (CDG) 和JG的挥发性油的疗效.
主要方法:
- 使用LC-TOF-MS的JGAE组件识别.
- 使用CA小鼠的体内研究和使用LPS受损的BEAS-2B细胞的体内研究.
- 代谢学分析,网络药理学,分子对接和途径验证 (PI3K/Akt).
主要成果:
- 与CDG和JG挥发性油相比,JGAE在改善CA方面表现出更高的有效性.
- JGAE降低了呼吸道的高反应性,炎症细胞,Th2细胞因子和MUC5AC,同时增加了AQP1和AQP5.
- 代谢学发现酸性代谢物的恢复;途径分析证实PI3K/Akt下调作为关键机制.
结论:
- 朱子生提取物 (JGAE) 显示出对控制感冒诱导喘 (CA) 的显著治疗潜力.
- 主要机制涉及PI3K/Akt信号通路的下调.
- 甘醇被确定为JGAE疗效的主要生物活性成分.
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