肠道微生物群和良性前列腺增生之间的因果关系:双样本孟德尔随机化分析,16SrRNA测序和临床回顾性研究
Ting-Ting Lin1,2, Bo-Han Lin1,2, Cheng-Long Zeng1,2
1Department of Urology, Urology Research Institute, the First Affiliated Hospital Fujian Medical University Fuzhou China.
Food science & nutrition
|November 24, 2025
概括
这项研究表明,肠道微生物群 (GM) 和良性前列腺增生 (BPH) 之间存在潜在的因果关系. 细菌Escherichia-Shigella被确定为BPH患者下泌尿道症状 (LUTS) 严重性的关键预测因子.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 遗传学 遗传学 是一个
背景情况:
- 新出现的证据表明肠道微生物群 (GM) 和良性前列腺增生 (BPH) 之间存在联系.
- 转基因和BPH之间的确切因果关系尚不清楚,需要进一步调查.
研究的目的:
- 使用孟德尔随机化 (MR) 调查肠道微生物群和良性前列腺增生之间的潜在因果关系.
- 探索特定肠道细菌在与BPH相关的下泌尿道症状 (LUTS) 严重性中的作用.
主要方法:
- 使用全基因组关联研究数据进行了两样本的门德尔随机化 (MR) 分析.
- 16S rRNA测序用于分析来自BPH患者和健康对照者的便样本.
- 统计方法包括逆方差加权 (IVW),加权中位数 (WM) 和MR-Egger分析,以及异质性和性质评估.
主要成果:
- MR 分析表明, *Phascolarctobacterium*, *Faecalibacterium* 和 *Escherichia-Shigella* 与BPH 风险增加有关,而 *Lactobacillus* 和 *Burkholderia* 则显示出保护作用.
- *Escherichia-Shigella*在各种方法中始终与BPH风险相关,并且在BPH患者中呈现出更多的丰度.
- 较高的*Escherichia-Shigella*相对丰度独立预测了严重的LUTS,并证明了LUTS严重性的显著预测值 (AUC=0.777).
结论:
- 这项研究提供了证据,支持肠道微生物群在良性前列腺增生症发展中的潜在因果作用.
- *Escherichia-Shigella*成为BPH下尿道症状严重性的重要细菌预测剂.
- 这些发现可能会为未来的治疗策略提供信息,以向微生物失生症来治疗BPH.
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