疾病中的O-GlcNAcylation调节的经典编程细胞死亡:分子交叉和治疗机会
Runyuan Liu1, Jingxuan Wei1, Zhengqing Luo1
1Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Frontiers in immunology
|November 24, 2025
概括
与O结合的β-N-乙糖胺 (O-GlcNAc) 是一种调节细胞功能的翻译后修饰. 本综述总结了O-GlcNAcc的情况.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 与O相关的β-N-乙糖胺 (O-GlcNAc) 是一种动态的翻译后修饰 (PTM),对于调节各种细胞过程至关重要.
- 虽然O-GlcNAc在细胞功能中的作用已经确立,但其在编程细胞死亡 (PCD) 途径中的特定参与和调节机制需要全面的总结.
- 关于O-GlcNAc与各种PCD类型之间的复杂关系的详细机制研究有限.
研究的目的:
- 为最近的研究提供最新的概述,将O-GlcNAc修饰与主要形式的编程细胞死亡联系起来.
- 探索O-GlcNAc在调节亡,自,热亡,铁亡和亡中的新兴作用.
- 讨论针对异常PCD相关疾病的O-GlcNAc的治疗潜力.
主要方法:
- 关于O-GlcNAc研究和编程细胞死亡的最新进展的文献综述.
- 对研究O-GlcNAcylation与特定PCD路径之间的机制联系的分析.
- 综合有关O-GlcNAc在涉及PCD的疾病背景中的作用的信息.
主要成果:
- O-GlcNAcylation显著影响多种编程细胞死亡途径,包括亡,自,热亡,铁亡和亡.
- 异常的O-GlcNAc模式与免疫-炎症性,神经退行性,心血管和代谢性疾病的发病有关.
- 调节O-GlcNAc水平或活性显示出在PCD过度或不足的疾病中进行治疗干预的潜力.
结论:
- O-GlcNAc是编程细胞死亡的关键调节者,影响着广泛的细胞命运.
- 了解O-GlcNAc和PCD之间的相互作用为疾病机制和潜在的治疗策略提供了新的见解.
- 向O-GlcNAc通路代表了治疗各种人类疾病的有希望的途径,包括癌症和炎症性疾病.
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