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由HMGB2通过ANGPT1/PI3K/AKT通路调节的NK细胞功能下降及其对食道状癌细胞的影响

Xiaodi Yin1, Huihong Cai1, Aohua Zhang1

  • 1Department of Clinical Laboratory, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in immunology
|November 24, 2025
PubMed
概括

高流动性组盒子2 (HMGB2) 在食道状细胞癌 (ESCC) 中损害了天然杀手 (NK) 细胞的抗瘤免疫力. 削减HMGB2通过ANGPT1/PI3K/AKT通路增强NK细胞功能,提供一种潜在的免疫治疗点.

关键词:
ANGPT1PT1 的意思这就是CRISPR-Cas9的特征.在 ESCC ESCC 的位置上.在HMGB2中,它是HMGB2.通过PI3K/Akt路径.自然杀手细胞是自然杀手细胞.

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