在极端老年人 (≥80岁) 中治疗一般性肌痛性肌痛的efgartigimod:一个多中心的回顾性现实研究
Ye Hong1, Chang-Wen Yuan2, Jie Lu3
1Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Frontiers in immunology
|November 24, 2025
概括
在80岁以上的患者中,efgartigimod有效治疗肌痛性肌痛症 (MG),显示出显著的症状减少和安全性. 患有急性恶化症的老年患者从这种免疫治疗中获得了最大的益处.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨髓灰质炎 (MG) 是一种自身免疫性疾病,影响神经肌肉结节.
- 针对性免疫疗法如efgartigimod提供了更好的疗效和安全性.
- 关于efgartigimod在老年患者,特别是80岁以上患者的使用数据有限.
研究的目的:
- 评估efgartigimod在80岁及以上的一般性MG患者的疗效和安全性.
- 评估老年人群中不同MG严重程度小组的治疗结果.
主要方法:
- 一项前性多中心研究,涉及12名80岁以上的泛性MG患者.
- 患者接受了efgartigimod治疗严重肌痛性肌痛症急性恶化,轻度/中度疾病或肌痛性肌痛危机.
- 使用MG-ADL,QMG和MGC尺度测量有效性;记录了不良事件.
主要成果:
- 在第4周观察到MG-ADL (52.2%),QMG (36.6%) 和MGC (48.2%) 评分的显著降低.
- 91.7%的患者迅速获得了临床上有意义的改善.
- 患有严重骨髓灰质炎急性恶化症的患者表现出最大的改善;不良事件是轻微的和短暂的.
结论:
- 埃夫加蒂格莫德是有效和安全的治疗老年患者 (80岁以上) 普遍的MG.
- 患有严重骨髓灰质炎急性恶化症的老年患者表现出最显著的益处.
- 这项研究支持efgartigimod作为这种脆弱患者群体的有价值的治疗选择.
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