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卵巢癌微环境中的巨和中性粒细胞

Kuang-Chao Cheng^1,2, Yu-Hsin Lin^1,2, Dao-Sian Wu^1,2

¹Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Frontiers in immunology

|November 24, 2025

概括

由于治疗不有效,卵巢癌 (OC) 的生存率仍然很差. 与瘤相关的巨细胞 (TAMs) 和中性粒细胞 (TANs) 驱动免疫抑制和疾病进展,表明新的治疗点.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
妇科瘤学妇科瘤学

背景情况:

尽管有针对性治疗的进展,但卵巢癌 (OC) 的生存率很低.
免疫疗法,包括免疫检查点抑制剂,在OC患者中显示出有限的疗效.
瘤微环境的复杂性,特别是免疫细胞的作用,对于治疗的无效性至关重要.

研究的目的:

审查瘤相关巨细胞 (TAMs) 和瘤相关中性粒细胞 (TANs) 在OC进展中的复杂作用.
阐明TAMs和TANs对卵巢癌免疫微环境的影响.
突出针对TAM/TAN介导过程的潜在治疗策略.

主要方法:

文学综述专注于卵巢癌中的先天性免疫细胞.
对TAM和TAN极化 (M1/M2和N1/N2) 的分析.
检查瘤微环境中的TAM/TAN相互作用.

主要成果:

TAMs表现出可塑性,M2型TAMs占主导地位,并促进免疫抑制,化学抵抗和转移.
TANs也表现出极化 (N1/N2) 并通过中性粒细胞外细胞陷促进瘤的进展.
M2 TAMs的存在与OC的更糟糕的预后相关.

结论:

TAMs和TANs显著影响卵巢癌的进展和治疗反应.
针对TAM/TAN介导的过程,为改善OC结果提供了一个有希望的治疗途径.
进一步了解OC瘤微环境中的免疫细胞相互作用对于开发有效治疗方法至关重要.

关键词:

免疫疗法免疫疗法卵巢癌是发生在卵巢的癌症.瘤微环境是一个微环境.与瘤相关的巨细胞 (TAMs)与瘤相关的中性粒细胞 (TANs)

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