补充メラトニン可改善2型糖尿病患者的认知功能:一项准实验性研究
Abida Pervaiz1, Usman Pasha2, Sadia Salman3
1Internal Medicine and Endocrinology, Jinnah Hospital Lahore/Allama Iqbal Medical College, Lahore, PAK.
Cureus
|November 24, 2025
概括
黑素补充剂改善了2型糖尿病患者的认知功能,提高了蒙特利尔认知评估 (MoCA) 评分. 它还降低了HbA1C和C反应蛋白 (CRP) 水平,这表明对糖尿病人的认知健康有好处.
科学领域:
- 内分泌学和新陈代谢学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病是一种代谢障碍,与由于葡萄糖和脂质代谢失调导致的认知障碍有关.
- 血糖失调是糖尿病患者认知障碍的潜在可逆风险因素.
- 在2型糖尿病 (T2DM) 患者的认知功能评估对于了解疾病影响至关重要.
研究的目的:
- 为了评估黑素补充剂对2型糖尿病患者认知功能的有效性.
- 评估蒙特利尔认知评估 (MoCA) 成绩的变化,作为认知改善的主要衡量标准.
- 检查黑激素对关键代谢标记物的影响,包括HbA1C,LDL-c,CRP和尿酸.
主要方法:
- 一项单盲,准实验性研究,涉及154名2型糖尿病患者和轻度至中度认知障碍患者 (MoCA分数10-25).
- 参与者每天接受5毫克口服黑激素或安慰剂,持续3个月.
- 在基线和12周后评估认知功能 (MoCA) 和生化标志物.
主要成果:
- 与安慰剂组相比,黑素组的MoCA得分显著改善 (p=0.016).
- 与安慰剂相比,黑素补充剂导致HbA1C (p=0.008) 和C反应蛋白 (CRP) 水平 (p=0.004) 的显著降低.
- 没有观察到黑激素对LDL-c或血清尿酸水平的显著影响.
结论:
- 黑素补充剂显著改善了2型糖尿病患者的认知功能,这是MoCA得分所表明的.
- 黑色素治疗也有效地降低了糖尿病患者的HbA1C和CRP水平.
- 黑素作为一种增强认知和代谢参数的辅助疗法,在2型糖尿病患者中表现有前途.
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