主要中枢神经系统淋巴瘤与免疫缺陷和失调有关:治疗和管理的挑战
Yuki Dan1, Akihiro Inoue1, Yukihiro Miyazaki2
1Neurosurgery, Ehime University Graduate School of Medicine, Toon, JPN.
Cureus
|November 24, 2025
概括
主要中枢神经系统淋巴瘤 (PCNSL) 在免疫缺陷和失调 (IDD) 是罕见的. 这一案例突显了移植患者的PCNSL,强调了免疫抑制患者的诊断考虑和治疗挑战.
科学领域:
- 神经瘤学神经瘤学
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 初级中枢神经系统淋巴瘤 (PCNSL) 在免疫缺陷和失调 (IDD) 的患者中不常见.
- 停止免疫抑制疗法是主要的治疗方法,但在实体器官移植 (SOT) 接受者中通常是不可行的.
- 本报告详细介绍了一例罕见的PCNSL病例,该病例发生在SOT接受者身上,其临床过程复杂.
研究的目的:
- 在移植后的免疫缺陷患者中报告PCNSL的独特病例.
- 讨论免疫抑制个体中中枢神经系统淋巴瘤的诊断挑战和管理策略.
主要方法:
- 一名47岁的女性移植接受者出现了神经症状.
- 诊断工作包括使用加多的MRI,扩散权重成像 (DWI),脑脊液分析和PET扫描.
- 组织病理学检查证实了扩散型大B细胞淋巴瘤 (DLBCL).
主要成果:
- 核磁共振显示了一个环增强的病变与相关的脑梗塞.
- 脑脊液中的β-2微球蛋白升高,血液中的EBV-DNA呈阳性.
- 尽管最初接受了Rituximab治疗,但瘤进展,需要进行放射治疗,导致缩.
结论:
- 应怀疑中枢神经系统淋巴瘤在免疫抑制患者,特别是SOT接受者,呈现中枢神经系统质量损伤.
- 在这一群体中,PCNSL的管理需要仔细考虑免疫抑制状态和治疗耐受性.
- 这一案例强调了在IDD中观察到的一些PCNSL病例中不寻常的临床过程和治疗耐药性.
相关概念视频
Primary Lymphoid Organs
14.5K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
14.5K
Secondary Lymphoid Organs
8.8K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.8K
Immunodeficiency Diseases
1.9K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.9K
Lymphoid Cells and Tissues
2.8K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.8K
Functions of the Lymphatic and Immune System
6.4K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.4K
Introduction to Lymphatic and Immune System
16.4K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
16.4K


