ARGscape:一个模块化,交互式的工具,用于操纵时空祖先重组图的空间时间
Christopher A Talbot1,2, Gideon S Bradburd1
1Department of Ecology and Evolutionary Biology, University of Michigan, 1105 North University Avenue, Ann Arbor, MI 48109, USA.
ArXiv
|November 24, 2025
概括
我们开发了ARGscape,这是一个交互式平台,用于在空间和时间之间可视化祖先重组图 (ARG). 这个工具通过简化复杂的家谱历史的探索来帮助人口遗传学研究.
科学领域:
- 人口遗传学 人口遗传学
- 计算生物学 计算生物学
- 生物信息学是一种生物信息学.
背景情况:
- 祖先重组图 (ARG) 和树序列对于了解人口历史至关重要.
- 由于缺乏交互式工具,对ARG进行可视化,特别是在地理背景下,具有挑战性.
- 现有的ARG分析方法往往分散在不同的平台上.
研究的目的:
- 介绍ARGscape,这是一个交互式平台,用于模拟,分析和可视化在空间和时间背景下ARG.
- 为探索ARG数据提供动态的2D和3D可视化.
- 将各种命令行,Python和基于R的ARG工具集成到一个统一的框架中.
主要方法:
- 开发ARGscape,使用Python FastAPI后端和React/TypeScript前端.
- 实现动态的2D和3D可视化功能.
- 集成ARG模拟,操纵和时空推理工具.
主要成果:
- ARGscape提供了一个用户友好的图形界面,用于探索跨空间和跨时间的ARG.
- 包含了一个新的"空间差异"可视化,用于对地理推理方法的定量比较.
- 该平台无地集成各种ARG分析工具,促进数据探索.
结论:
- ARGscape降低了空间时间ARG分析在研究和教育中的进入障碍.
- 该平台支持在人口遗传学中进行新型数据探索和假设生成.
- ARGscape提供了一个统一的框架,用于交互式可视化和分析ARG.
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