炎症促进胰岛素抵抗:基于从全血细胞计数中获得的炎症指数的分析
Xinzhong Zhang1, Ying Wei1, Ying Wang2
1Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People's Republic of China.
Journal of inflammation research
|November 24, 2025
概括
系统性炎症指数的升高,如中性粒细胞与淋巴细胞比率 (NLR) 和系统性免疫炎症指数 (SII),与代谢功能障碍有关. 这些血清标记可能有助于识别胰岛素抵抗的早期迹象.
科学领域:
- 生物医学研究的研究.
- 代谢健康 代谢健康
- 炎症标志物的炎症标志物
背景情况:
- 系统性炎症指数,包括系统性炎症总指数 (AISI),单细胞与淋巴细胞比率 (MLR),中性粒细胞与淋巴细胞比率 (NLR),中性粒细胞与血小板比率 (NPR),系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI),都与代谢障碍有关.
- 脂肪组织胰岛素耐药性 (Adipo-IR) 和胰岛素耐药性的恒温模型评估 (HOMA-IR) 是代谢功能障碍的关键指标.
研究的目的:
- 调查六种系统性炎症指数与Adipo-IR之间的关联.
- 检查这些炎症指数与HOMA-IR之间的关系.
主要方法:
- 一项涉及北京朝阳医院11416名参与者的横截面研究.
- 用多种线性和逻辑回归模型来分析关联.
- 根据年龄,性别和BMI进行了分组分析,以探索效果的修改.
主要成果:
- 所有六个炎症指数都与阿迪波-IR显著相关,较高的水平与风险增加相关.
- 与MLR不同的是,AISI,NLR,NPR,SII和SIRI与HOMA-IR显示出显著的关联.
- 在女性中,NLR和SII与Adipo-IR的关联较强;在年轻成人 (18-44岁) 中,SII与Adipo-IR和HOMA-IR的关联较强.
结论:
- 系统性炎症指数的升高与Adipo-IR和HOMA-IR有关.
- 这些发现凸显了常规血液计数衍生指数作为代谢功能障碍的经济有效的早期指标的潜力.
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