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高剂量皮质类固醇在重症COVID-19患者:苏里南的一项回顾性队列研究

Katrijn Daenen^1,2, Anfernee Neus³, Lycke Woittiez⁴

¹Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.

Journal of inflammation research

|November 24, 2025

概括

高剂量皮质类固醇 (HDS) 在苏里南的严重COVID-19肺炎患者中没有改善结果或增加超级感染. 标准剂量德克萨米他仍然是COVID-19推的皮质类固醇治疗方法.

科学领域:

关键护理医学关键护理医学
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

高剂量皮质类固醇 (HDS) 用于非COVID-19 ARDS.
标准剂量的甲 (每天6毫克) 降低了需要氧气或通风的COVID-19患者的死亡率.
HDS有时用于严重的COVID-19肺炎,以进一步降低死亡率.

研究的目的:

评估与标准剂量德克萨米他 (SDS) 相比,HDS对重症监护室 (ICU) 死亡率的影响.
评估HDS对苏里南严重COVID-19肺炎患者超级感染率的影响.

主要方法:

在苏里南的ICU中,对103名患有严重COVID-19肺炎的患者进行了回顾性队列研究 (2020年6月至2021年10月).
患者接受了SDS和/或HDS (每天甲松>6毫克).
时间更新的Cox生存模型和Chi-square测试分析了死亡率预测因素和超级感染.

主要成果:

在36%的患者中,HDS被用于治疗.
多变量分析确定了年龄和侵入性机械通风作为显著的死亡率预测因素.
时间更新的生存分析显示,HDS没有显著的益处或危害 (HR 1.99,p=0.15) 并没有增加超级感染 (p=1.00).

结论:

这项研究发现,在严重的COVID-19肺炎中,与SDS相比,HDS没有改善结果或增加超级感染.
研究结果不支持在这个人群中增加皮质类固醇剂量超过标准治疗.
确定死亡风险因素可以指导高风险患者的识别.

关键词:

在 COVID-19 疫情中,这是一种皮质类固醇.传染病是一种传染性疾病.病毒学病毒学

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