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在患有长期意识障碍的患者中,口腔微生物组发生变化

Mingwei Xu¹, Zhuolin He¹, Jiajia Zhou¹

¹Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.

Journal of oral microbiology

|November 24, 2025

概括

口腔微生物组在患有长期意识障碍 (pDoC) 的患者中不同,在植物状态 (VS) 中的多样性减少. 这些变化可能会影响大脑功能,并为临床策略提供信息.

科学领域:

微生物组研究的研究.
神经科学是一个神经科学.
临床诊断临床诊断临床诊断

背景情况:

主体微生物组影响大脑功能和疾病.
口腔微生物组在长期意识障碍 (pDoC) 中的作用还没有得到充分研究.

研究的目的:

描述pDoC患者的口腔微生物群在意识水平 (植物状态,最小意识状态,从最小意识状态出现) 的差异.
调查抗生素使用对pDoC口腔微生物群的影响.
评估口腔微生物群对于pDoC预后的预测潜力.

主要方法:

使用16S核糖体RNA测序,分析了89名pDoC患者的口腔微生物群.
在不同意识状态中对口腔微生物群多样性和组成进行比较分析.
对抗生素影响的评估和预后模型的开发.

主要成果:

在植物状态 (VS) 中观察到口腔微生物多样性的减少,与从最小意识状态 (EMCS) 中出现的组相比.
五种特定的种群 (例如,Streptococcus danieliae,Corynebacterium durum) 在VS和EMCS之间显示出显著的差异.
抗生素的使用显著改变了VS患者的口腔微生物群,但不是MCS或EMCS患者.
基于微生物群的预测模型实现了高预测准确度 (AUC为0.820和0.920).

结论:

口腔微生物组的改变在pDoC患者中很明显,可能与疾病进展有关.
这些发现强调了在pDoC的临床策略中考虑口腔微生物群的重要性.
口腔微生物群概况显示,有望预测有意识障碍的患者的结果.

关键词:

16S rRNA 测序的测序方法意识的障碍意识的障碍抗生素抗生素是一种抗生素.口腔微生物组是口腔的微生物组.预后预后预后

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