普遍预防肝细胞癌的世俗趋势:台湾,波兰和比利时的经验
Zong-Ze Huang1, Karol Żmudka2, Valerio Ruggiano3
1Department of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
World journal of gastrointestinal oncology
|November 24, 2025
概括
在台湾和波兰,肝细胞癌 (HCC) 发病率下降,这可能是由于对乙型肝炎病毒的控制. 然而,弗兰德斯的HCC病例率上升,可能与C型肝炎病毒的流行有关.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 肝癌,特别是肝细胞癌 (HCC),是一个重大的全球健康挑战.
- 了解不同地区HCC发病率的变化对于确定影响因素和为公共卫生政策提供信息至关重要.
研究的目的:
- 从2000年到2019年,分析台湾,波兰和比利时的弗兰德斯的HCC的长期趋势和疾病模式.
- 调查这些不同人群中对HCC发病率的年龄,周期和队列效应.
主要方法:
- 一项基于人口的队列研究,利用来自台湾,波兰和弗兰德斯的癌症登记数据.
- 计算年龄标准化发病率 (ASIR) 和年度百分比变化.
- 应用年龄时期队列分析来评估时间趋势和风险因素.
主要成果:
- 台湾和波兰在男性和女性中显示出HCCASIR的下降趋势.
- 在研究期间,比利时的弗兰德斯 (Flanders) 经历了HCC ASIR显著增加.
- 队列分析显示出明显的模式,台湾显示率比率上升然后下降,波兰持续下降,弗兰德斯在出生队列中增加.
结论:
- 台湾和波兰的HCC发病率下降可能归因于成功的乙型肝炎病毒 (HBV) 免疫计划和抗病毒疗法.
- 佛兰德斯的HCC发病率增加可能与C型肝炎病毒 (HCV) 影响人口中风险因素的更高流行率有关.
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