皮肤刻字和精神分裂症:关于神经发育生物标志物的全面审查
Elie Bou Farah1, Karen Beydoun2, Lynn Nasr2
1Department of Dermatology, University of Balamand, Beirut 0000, Beyrouth, Lebanon.
World journal of psychiatry
|November 24, 2025
概括
皮肤刻字,指纹图案的研究,可以作为精神分裂症的非侵入性生物标志物. 这些模式中的异常与精神分裂症患者的神经发育障碍有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 精神分裂症是一种复杂的神经精神疾病,具有遗传和环境起源.
- 皮肤刻字,研究表皮脊图案,在关键的神经发育时期形成.
- 皮肤刻字的变化可能表明早期的神经发育障碍.
研究的目的:
- 审查和综合有关精神分裂症皮肤刻字模式的证据.
- 探索皮肤刻字作为精神分裂症潜在的非侵入性生物标志物.
- 为了比较精神分裂症与双相情感障碍的皮肤图标发现.
主要方法:
- 进行了PubMed和Scopus (2004年1月至2024年12月) 的系统文献搜索.
- 包括原始研究,评论和对精神分裂症和相关疾病中的皮肤刻字的元分析.
- 不包括动物研究,非定量病例报告和非英语论文.
主要成果:
- 一致的发现包括减少总脊数,增加波动不对称性,以及精神分裂症中异常的手掌纹.
- 双胞胎研究表明,产前环境影响有助于这些异常.
- 皮肤刻字图案显示了一些重叠,但精神分裂症和双相情感障碍之间也有区别.
结论:
- 皮肤刻字分析是一种稳定,廉价,非侵入性的工具,有可能作为精神分裂症神经发育障碍的辅助生物标志物.
- 方法的变化目前限制了临床应用.
- 未来的研究应该标准化技术,并与基因组和神经成像数据集成.
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