羽毛灵感的Janus接口与时空离子编程用于糖尿病伤口感染控制和再生愈合
Chaoyang Huang1, Lianglong Chen1, Huihui Zhang1
1Department of Burns, Nanfang Hospital, Southern Medical University, Jingxi Street, Baiyun District, Guangdong, 510515, PR China.
Materials today. Bio
|November 24, 2025
概括
一种以水鸟羽毛为灵感的新的Janus连衣,可以加速糖尿病足的愈合. 这种先进的伤口带提供了物理屏障和受控的治疗离子释放,促进组织修复和减少感染风险.
科学领域:
- 生物材料工程 生物材料工程
- 再生医学是一种再生医学.
- 伤口愈合 治愈 伤口愈合
背景情况:
- 由于感染风险和复杂的微环境,糖尿病足 (DFU) 存在重大挑战.
- 目前的治疗方法往往不足,需要先进的伤口护理解决方案.
- 需要一种结合物理保护和生物干预的双重作用包裹.
研究的目的:
- 开发一种由层次工程设计的Janus包裹,用于治疗固的伤口.
- 为了研究带提供物理屏障和治疗离子的受控释放的能力.
- 在糖尿病感染伤口模型中评估包裹在促进伤口愈合方面的有效性.
主要方法:
- 电被用来创建一个具有明显的疏水性和疏水性层的Janus连接剂 (PPT@PG-BG).
- 包裹集成治疗性离子 (Mg2+,Zn2+,Ce3+) 进行时空释放.
- 评估了敷料对免疫血管原本平衡,抗氧化途径,巨细胞两极分化和新血管化的影响.
主要成果:
- 在糖尿病感染的伤口模型中,Janus包裹实现了97.85%的伤口关闭.
- 它有效地激活了p-ERK/Nrf2抗氧化途径,并促进了M2巨细胞的两极分化.
- 观察到增强的新血管化和恢复的免疫-血管原性平衡.
结论:
- 开发的Janus包裹为治疗复杂,难以愈合的伤口提供了一个有希望的策略.
- 它的物理保护和多离子协同生物治疗的结合加快了伤口愈合.
- 这种方法具有显著的临床转化和改善患者结果的潜力.
相关概念视频
Phases of Wound Repair
7.8K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
7.8K
Clinical Applications of Epidermal Stem Cells
3.2K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.2K
Stem Cell Therapy for Tissue Regeneration
4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K
Tissue Renewal without Stem Cells
2.1K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
2.1K


