奎尔素通过调节由线粒体驱动的线粒体功能障碍来预防传染性胃肠炎病毒诱导的肠炎
Kang Wang1,2, Zhentao He1,2, Yan Li1,2
1Institute of Animal Nutrition, Sichuan Agricultural University, Sichuan Province, Chengdu, 611130, People's Republic of China.
International journal of biological sciences
|November 24, 2025
概括
传染性胃肠炎病毒 (TGEV) 感染会通过过度激活线粒引起肠道损伤. 天然化合物奎尔丁通过恢复线粒体功能和减少过度的线粒细胞衰变来减轻TGEV诱导的炎症.
科学领域:
- 病毒学 病毒学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 传染性胃肠炎病毒 (TGEV) 在小猪中引起严重的肠道疾病.
- 线粒体功能障碍与冠状病毒引起的炎症有关,但线粒体在TGEV病变发生中的作用尚不清楚.
研究的目的:
- 研究菌在TGEV病变发生中的作用.
- 为了确定可以减轻TGEV诱导的肠道炎症的天然化合物.
主要方法:
- 在感染TGEV的猪肠细胞中选天然植物化合物.
- 评估奎尔丁对病毒载荷,细胞病变效应和线粒体功能的影响.
- 研究PINK1/Parkin介导的线粒,线粒体膜潜能,mtROS和炎症信号通路 (NF-κB,JAK/STAT) 的参与.
- 在感染TGEV的小猪模型中验证发现.
主要成果:
- 奎尔素减轻了TGEV诱导的损伤,并减少了病毒载量,而没有直接的抗病毒活性.
- TGEV感染过度激活了PINK1/帕金介导的线粒,导致线粒体功能障碍和炎症.
- 奎尔素通过抑制过度的线粒体,保持线粒体潜力和mtDNA,减少氧化应激来恢复线粒体功能.
- 奎尔的抗炎作用与维护线粒体平衡和抑制病理性线粒体流动有关.
- 在TGEV感染的小猪中,过度的线粒细胞衰变与肠道炎症相关.
结论:
- 在TGEV的发病过程中,神经菌驱动的线粒体功能障碍和随后的肠道炎症.
- 奎瑞是一种潜在的线粒体向的天然化合物,用于治疗TGEV诱导的肠炎症.
- 向线粒可能是冠状病毒引起的肠炎的新疗法策略.
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