巨细胞免疫代谢在肺恒温和慢性肺部疾病中的作用
Cong Xie1,2, Maimaititusun Yalikun1,3, Zhenhui Ruan1,4
1Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China.
International journal of biological sciences
|November 24, 2025
概括
肺部巨细胞代谢的改变导致慢性呼吸道疾病,如喘,COPD和IPF. 恢复新陈代谢平衡为这些疾病提供了新的治疗策略.
科学领域:
- 肺免疫学 肺免疫学
- 细胞代谢的细胞代谢.
- 慢性肺部疾病 慢性肺部疾病
背景情况:
- 膜巨细胞对于肺免疫平衡和修复至关重要.
- 巨细胞的代谢重编程是它们功能和行为的关键.
- 巨细胞中的病理代谢变化有助于慢性肺部疾病.
研究的目的:
- 审查目前关于肺部巨细胞免疫代谢的知识.
- 探索巨细胞代谢在慢性呼吸道疾病中的作用.
- 讨论针对巨细胞代谢的治疗策略.
主要方法:
- 对肺部健康和疾病中的巨细胞代谢研究的文献综述.
- 对喘,COPD和IPF巨细胞中的代谢途径的分析.
- 对代谢失调的治疗干预措施的检查.
主要成果:
- 喘相关的巨细胞显示脂肪酸氧化和脂质谱的变化.
- 慢性肺炎巨体表现出线粒体功能障碍,增强的葡萄糖分解和铁过载.
- IPF巨体显示失调的葡萄糖分解和氧化途径,失去关键代谢物.
结论:
- 疾病特异性的巨细胞代谢重编程在慢性肺病中维持了不适应的表型.
- 向巨细胞代谢提供了有前途的治疗途径.
- 恢复新陈代谢平衡可能为喘,COPD和IPF提供新的治疗方法.
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