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Updated: Jan 10, 2026

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通过全跨视网膜激活GSDME会增加对光受体铁的敏感性

Bo Yang1,2, Kunhuan Yang1,2, Yuling Chen1,2

  • 1Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361003, China.

International journal of biological sciences
|November 24, 2025
PubMed
概括

全透视视网膜 (atRAL) 清除受损导致Stargardt病和AMD中的视力丧失. 通过atRAL激活Gasdermin E (GSDME) 驱动光受体细胞死亡,但阻断GSDME或线粒体ROS可以防止这种损伤.

关键词:
在GSDME中,GSDME是GSDME.完全通过视网膜的全网膜.铁性化 (ferroptosis) 是一种斑点退化症 斑点退化症一个光感受器.

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