多部位骨 necrosis 长期皮质体治疗:一个案例报告
Ayyappan V Nair1, B Sai Theja2, J Sreejith Thampy2
1Department of Orthopaedics, Bengaluru Shoulder Institute, Bengaluru, Karnataka, India.
Journal of orthopaedic case reports
|November 24, 2025
概括
多部位骨髓缩 (MSON) 是一种罕见的疾病,通常与皮质类固醇使用有关. 这项案例研究表明,核心减压,骨髓吸附度,和alendronate可以减缓MSON的进展,与张力筋部移植有效的部参与.
科学领域:
- 整形外科 整形外科 整形外科
- 骨生物学 骨生物学 骨生物学
- 再生医学是一种再生医学.
背景情况:
- 骨髓缩 (ON) 是由于血液流动受损而导致的骨细胞死亡.
- 多部位骨髓缩 (MSON) 影响≥3个解剖部位,通常与高剂量皮质类固醇使用有关.
- 在年轻成年人中对ON的管理进行了辩论,核心减压 (CD) 对于早期阶段有效 (Ficat I-II).
研究的目的:
- 在使用皮质类固醇的年轻成年人中报告MSON病例.
- 为了评估连续治疗的疗效,包括CD,骨髓吸附缩物 (BMAC),阿伦德罗纳酸和张张带 (TFL) 移植.
主要方法:
- 一名怀疑MSON的27岁女性接受了MRI确认.
- 顺序治疗涉及受影响关节的CD和BMAC,口服阿伦德罗纳酸和TFL肌肉脚骨移植用于部病变.
- 随访包括评估所有受影响关节的疾病进展情况.
主要成果:
- CD,BMAC和alendronate减少了MSON在肩和脚关节的进展.
- 在TFL肌肉脚部移植后,有效地减少了部疾病的进展.
- 综合治疗方法对管理MSON产生了积极影响.
结论:
- 患有关节疼痛和类固醇病史的年轻人应对MSON进行评估.
- 序列性CD,BMAC和alendronate在管理MSON进展方面表现有前途.
- TFL移植是部MSON管理的一个可行的选择.
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