在COVID-19后综合征中功能性嗅觉障碍和疲劳,包括ME/CFS - 一项纵向前性观察性研究
Lil Meyer-Arndt1,2,3,4,5,6, Greta Pierchalla7, Lukas Mödl8
1Experimental and Clinical Research Center, A Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin, Germany.
Brain, behavior, & immunity - health
|November 24, 2025
概括
后COVID-19综合征 (PCS) 可能导致长期的嗅觉问题. 持续的气味识别障碍可能表明正在进行的中央处理困难,并与PCS患者的认知和身体功能相关.
科学领域:
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19综合征 (PCS) 经常涉及持续的嗅觉障碍和疲劳.
- 一部分PCS患者表现出与肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 相匹配的症状,称为PCS-ME/CFS.
- 嗅觉功能障碍作为PCS诊断和预后标志物的作用需要进一步调查.
研究的目的:
- 探索PCS,疲劳和嗅觉功能之间的关系.
- 研究嗅觉障碍作为PCS的潜在诊断和预后标志物.
- 评估PCS患者随时间推移的嗅觉功能,疲劳,认知和身体表现.
主要方法:
- 在COVID-19后28个月内,在45名PCS患者 (22名PCS,23名PCS-ME/CFS) 中使用扩展的嗅探棒测试来评估嗅觉功能.
- 评估疲劳,与健康相关的生活质量,认知功能和握力,使用验证的问卷和标准化测试.
- 与临床结果和性能指标相关的嗅觉测量.
主要成果:
- 两组PCS和PCS-ME/CFS都显示了显著的嗅觉功能的改善,在20个月后达到正常状态.
- 嗅觉识别比其他嗅觉测量更长时间保持受损,这表明持续存在的中央处理问题.
- 嗅觉障碍与认知,身体和精神表现相关,在PCS组中联系更强.
结论:
- 气味识别可能作为COVID-19后中央处理困难的长期指标.
- 嗅觉,认知和身体表现之间的相关性表明共享的潜在病理生理机制.
- 早期的嗅觉改善可能预测PCS患者的更好的长期认知结果,表明潜在的预后作用.
相关概念视频
01:03Olfactory Receptors: Location and Structure
11.1K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.1K
01:21Fatigue
784
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
784
01:20COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
01:25Olfaction
48.0K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
48.0K