以往SARS-CoV-2感染后登革热的风险:基于人口的队列研究
Liang En Wee1,2,3, Jue Tao Lim4, An Ting Tay1
1Communicable Diseases Agency, Singapore.
The Lancet regional health. Western Pacific
|November 24, 2025
概括
COVID-19 (冠状病毒疾病2019) 幸存者面临着登革热病毒 (DENV) 感染的风险增加,特别是DENV3,长达300天. 这种风险凸显了热带地区持续实施公共卫生战略的重要性.
科学领域:
- * 传染病流行病学
- * 病毒免疫学
- * * 公众健康
背景情况:
- *登革热病毒 (DENV) 和SARS-CoV-2 (导致COVID-19的病毒) 是热带地区的特有病.
- *由于抗原交叉反应和交叉保护,DENV和SARS-CoV-2感染之间存在潜在的相互作用.
- *在之前的COVID-19诊断后,随后发生DENV感染的风险需要评估.
研究的目的:
- *为了评估COVID-19后DENV感染的风险.
- *评估COVID-19疫苗接种状态对DENV感染风险的影响.
- * 为了研究SARS-CoV-2和DENV感染之间的潜在相互作用.
主要方法:
- * 在新加坡使用国家登记册进行了回顾性队列研究.
- *成年人 (≥18岁) 在2021年9月至2022年12月期间被分为SARS-CoV-2感染者和检测负的队列.
- *重叠加权考克斯回归被用于分析COVID-19后31-300天DENV感染的风险,并对其他感染和流感疫苗接种进行控制.
主要成果:
- *在COVID-19后31-300天观察到DENV感染的风险显著增加 (aHR = 1.10),与DENV3激增相吻合.
- *COVID-19后的DENV感染的过重负担是每1000个人中0.36例.
- *在未接种疫苗的COVID-19病例中风险最高,在接种了四剂或更多剂量的疫苗的人群中风险不高;对照结果没有显著增加.
结论:
- *在SARS-CoV-2感染后,DENV感染的风险略微增加,主要是DENV3,持续长达300天,主要是Omicron.
- *虽然并不是抗体依赖增强的最终证据,但这些发现表明潜在的相互作用需要进一步研究.
- * 包括疫苗接种在内的公共卫生策略在热带/亚热带地区仍然至关重要,这些地区是COVID-19和DENV的共同流行地.
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