低骨矿物质密度与更高的静脉血栓塞栓症风险评分在绝经后的女性相关
Chen Gong1,2, Feng Ling1, Yichao Mao3
1Department of Orthopedics, Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, 225300, People's Republic of China.
International journal of women's health
|November 24, 2025
概括
较低的骨矿物质密度 (BMD) 与更高的静脉血栓塞栓症 (VTE) 风险有关. 这表明BMD可能是一个新的静脉瘤风险生物标志物,可能指导血栓预防策略.
科学领域:
- 老年学是指老年学的学科.
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
背景情况:
- 静脉血栓栓塞 (VTE) 和骨质疏松症在绝经后妇女中很常见.
- 雌激素缺乏和衰老是共同的风险因素.
- 骨矿物质密度 (BMD) 降低和血栓形成之间的联系正在出现.
研究的目的:
- 调查绝经后妇女的BMD和VTE风险之间的关联.
- 为了探索BMD作为潜在的VTE风险生物标志物.
主要方法:
- 纳入了511名绝经后妇女.
- 使用双能X射线吸收计 (DXA) 测量 BMD.
- 使用卡普里尼风险评估得分来评估VTE风险.
主要成果:
- 骨质疏松症患者的卡普里尼分数 (6.20 ± 3.20) 比正常骨质量 (5.40 ± 2.60; p=0.019) 的患者高.
- 随着BMD的下降,D-二聚合物2 (DD2) 和纤维素原 (FIB) 水平增加.
- 最低的BMD是增加静脉瘤风险的独立预测因子 (OR=0.02;p<0.01).
结论:
- 较低的BMD独立地与绝经后妇女的VTE风险增加有关.
- 骨质量可能成为VTE风险的新生物标志物.
- 建议将 BMD 纳入风险模型,并考虑低 BMD 个体的血栓预防.
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