机械压力介导的免疫和炎症调节:基于两个数据库的机械免疫学的图书统计和可视化分析
Jiayuecheng Pang1, Yicheng Ma1, Hongchao Huang1
1Department of Burn Trauma and Wound Repair, The First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai, People's Republic of China.
Frontiers in medicine
|November 24, 2025
概括
机体免疫学研究正在激增,揭示了T细胞和巨细胞等关键点. 这项研究绘制了目前免疫-炎症调节的热点和未来方向.
科学领域:
- 生物力学 生物力学
- 免疫学 免疫学 免疫学
- 跨学科科学 跨学科科学
背景情况:
- 机械压力会影响细胞过程和免疫反应.
- 机械免疫学结合了生物力学和免疫学来研究这些影响.
- 精确的机制需要进一步阐明.
研究的目的:
- 确定机械免疫学的当前研究热点.
- 分析这个新兴领域的研究状况.
- 为未来的调查提供研究路线图.
主要方法:
- 对来自Web of Science的1901篇文章和来自Scopus的2954篇文章进行了图书统计分析.
- 使用图形工具进行数据处理和视觉分析.
- 对期刊,作者,地理,引用和关键词进行分类分析.
主要成果:
- 美国和中国领导研究;加利福尼亚大学系统是一个关键机构.
- 自2021年以来,观察到显著的研究激增,如T细胞和巨细胞两极分化等新集群.
- 新兴的目标包括Piezo1和YAP/TAZ复合体,在伤口愈合和肠道微生物群中具有应用.
结论:
- 机械免疫学正在经历一场研究激增,确定了热点和未来方向.
- 新的机械敏感标对于免疫-炎症调节至关重要.
- 这项研究为该领域的研究人员提供了一份路线图.
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