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Updated: Jan 10, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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用泛RAF抑制剂对NSCLC中的BRAFII和III类突变进行向Exarafenib揭示了ARAF-KSR1-介导的抵抗和理性组合策略

Tadashi Manabe1,2,3, Hannah C Bergo1,2,3, Qingtian Li1,2,3

  • 1Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.

Research square
|November 24, 2025
PubMed
概括

在非小细胞肺癌 (NSCLC) 中,BRAF突变很常见. 一种新药物exarafenib对II/III类BRAF突变NSCLC具有前景,组合疗法克服了耐药性.

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Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells06:44

Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells

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Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib09:38

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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