肠道微生物群:一种调节病毒和癌症疫苗免疫潜力的新因素
Agathe Carrier1,2,3, Paolo Manghi4,5, Carolina Alves Costa Silva1,2,3
1Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France.
Research square
|November 24, 2025
概括
疫苗的有效性在个体之间有很大差异. 通过先进的诊断来确定肠道微生物群的健康状况,可以预测和潜在地改善对疫苗的免疫反应,优化公共卫生策略.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
- 疫苗学 疫苗学 疫苗学
背景情况:
- 疫苗对公共卫生至关重要,可以预防传染病和癌症.
- 目前的疗效标志物,如抗体标位,具有很高的可变性.
- 先进的T细胞测试可以评估疫苗诱导的淋巴细胞反应.
研究的目的:
- 调查细胞和幽默免疫反应对不同的疫苗配方.
- 确定影响疫苗疗效异常值的因素.
- 探索肠道微生物群在疫苗反应中的作用.
主要方法:
- 分析了五个独立队列 (医疗保健工作者,健康人群,癌症患者) 的免疫反应.
- 评估各种免疫剂 (非复制,病毒,mRNA,,细胞,病毒颗粒).
- 枪头元基因组学和机器学习 (TOPOSCORE) 来评估肠道失调.
主要成果:
- 大约20%的未复制疫苗接种者显示抗体和Th1/Tc1反应不足.
- 大约9%的活体疫苗接种者是超响应者.
- 疫苗反应异常值与基线肠道失调有关.
结论:
- 肠道功能障碍是影响疫苗疗效的重要因素.
- 需要诊断工具来识别肠道失生症.
- 以微生物群为中心的干预措施可以提高大规模疫苗接种结果.
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