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Updated: Jan 10, 2026

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
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In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

Published on: September 7, 2022

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通过SARS-CoV-2聚合酶和S759A耐药性的选择性remdesivir整合的结构基础

Kalyan Das1, Calvin Gordon2, Mizar Oliva1

  • 1KU Leuven.

Research square
|November 24, 2025
PubMed
概括

雷梅西维尔三酸盐 (RTP) 被SARS-CoV-2RNA依赖RNA聚合酶 (RdRp) 纳入,但连续的纳入受到ATP存在和结构刚性的限制. 这一发现影响了新型抗病毒核酸类类似物的设计.

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