长期COVID:肺部病理生理学及其与认知功能障碍的关系
Keegan R Staab1, Marrissa J McIntosh1, Abhilash S Kizhakke Puliyakote1
1University of Iowa.
Research square
|November 24, 2025
概括
长期的COVID可能会导致与肺部问题相关的持久认知问题. 长期COVID患者的肺气交换受损与睡眠问题和认知缺陷相关,这表明存在联系.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
背景情况:
- COVID-19 (长期COVID) 后急性后续症状呈现出持续的身体和认知症状.
- 长期COVID肺部病理生理学和认知功能障碍之间的关系尚不清楚.
研究的目的:
- 探索长期COVID患者肺功能和认知表现之间的联系.
- 为了研究肺气交换,脑成像发现和认知症状之间的相关性.
主要方法:
- 从一个后COVID-19诊所招募了长COVID参与者.
- 使用了PROMIS问卷,NIHTB-CB,肺功能测试,结构/功能大脑MRI和129XeMRI.
- 使用 Spearman 部分相关性对年龄进行调整,评估了双变量关系.
主要成果:
- 普罗米斯得分揭示了显著的疲劳,焦虑,抑郁,睡眠障碍和认知功能的降低.
- 接受NIHTB-CB的客观认知表现通常在正常范围内.
- 减少129XeMRI气体交换与睡眠障碍增加,执行功能障碍和大脑输液升高相关.
结论:
- 研究结果表明,在长期COVID中,肺部病理生理学和认知功能障碍之间存在联系.
- 在长期COVID患者中持久的呼吸和认知症状可能相互联系.
- 需要进一步的研究来阐明这些关联背后的机制.
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