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在甲状腺功能低下患者中探索PEG沉后的TSH恢复

Jing Yin¹, Zhanjun Mei¹, Bo Zhang¹

¹Department of Nuclear Medicine, The Second Affiliated Hospital of Chengdu Medical College Nuclear Industry 416 Hospital, Chengdu, Sichuan, China.

Frontiers in endocrinology

|November 24, 2025

概括

一种新方法有助于检测甲状腺刺激激素 (TSH) 测试中的血清大分子干扰. 低于28%的TSH恢复率表明甲状腺功能低下患者的干扰.

科学领域:

内分泌学在内分泌学.
临床化学临床化学

背景情况:

甲状腺疾病是常见的内分泌疾病,需要准确的实验室诊断.
甲状腺功能测试的免疫测试容易受到血清大分子的干扰,这可能会影响临床决策.

研究的目的:

开发和评估一种新的方法,用于评估甲状腺刺激激素 (TSH) 检测中的血清宏分子干扰.
在患有甲状腺功能障碍的患者中建立TSH测试临床评估的参考标准.

主要方法:

使用聚乙烯糖醇 (PEG) 沉方法来评估TSH恢复率.
分析了160名甲状腺功能低下症/亚临床甲状腺功能低下症患者和160名健康对照人群.
计算了TSH恢复率,并确定了截止值.

主要成果:

在患者组和对照组之间观察到TSH恢复率的显著差异 (P<0.05).
确定了28%的TSH恢复率截止值.
在36.6%的甲状腺功能低下症和39.7%的亚临床甲状腺功能低下症病例中检测到宏分子干扰.

结论:

低于28%的TSH恢复率表明潜在的血清大分子干扰在甲状腺功能低下症和亚临床甲状腺功能低下症.
这种方法为TSH测试的临床评估提供了一个新的参考.
在低TSH恢复率的甲状腺功能低下患者中应考虑干扰.

关键词:

甲状腺功能低下症甲状腺功能低下症聚乙烯葡萄糖 (PEG) 是一种聚乙烯葡萄糖.收回率的回收率是多少亚临床的甲状腺功能低下症甲状腺刺激激素激素是什么

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