在奥米克和神经成像中,双极性障碍的生物标志物
Donglin He1, Jingzhi Yang2, Zuowei Wang3,4
1School of Medicine, Shanghai University, Shanghai, 200444, China.
Journal of pharmaceutical analysis
|November 24, 2025
概括
确定双极性障碍 (BD) 的生物标志物对于准确诊断至关重要,特别是将其与单极性抑郁症区分开来. 本综述总结了BD目前的omics和神经成像生物标志物研究.
科学领域:
- 精神病学是一个精神病学.
- 生物标志物 生物标志物
- 神经成像是一种神经成像.
背景情况:
- 双极性障碍 (BD) 影响全球1%的人口,并以躁狂和抑郁症为特征.
- 准确诊断BD,特别是将其与单极抑郁症 (UD) 区分开来,仍然是一个重大的临床挑战.
- 需要客观的诊断标准来准确诊断和治疗BD.
研究的目的:
- 系统地审查当前关于双相情感障碍 (BD) 生物标志物的研究.
- 总结与BD生物标志物相关的omics和神经成像研究的发现.
- 突出生物标志物的潜力,以建立BD的客观诊断标准.
主要方法:
- 通过使用关键词"BD"",诊断"和"生物标志物"进行了系统的文献搜索.
- 审查包括了110项研究.
- 研究对BD的omics和神经成像生物标志物的研究进行了检查.
主要成果:
- 生物标志物显示出对BD的客观诊断有希望.
- 目前正在积极探索omics和神经成像方法来识别BD生物标志物.
- 目前的研究表明,生物标志物可能有助于区分BD和UD.
结论:
- 生物标志物对于开发BD的客观诊断标准至关重要.
- 需要在奥米克和神经成像领域进行进一步的研究,以确定可靠的BD生物标志物.
- 识别强大的生物标志物可以促进早期和更准确的诊断和治疗BD.
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