微量元素状况与心房动在患有膜心脏病的患者之间的关系
Xiang Liu1,2, Yijia Shao3, Zirui Huang1,2
1Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Frontiers in cardiovascular medicine
|November 24, 2025
概括
尿液中的微量元素含量与心脏膜疾病 (VHD) 患者的心房动 (AF) 有关. 铜和的含量较高,和的含量较低与AF有关,这表明AF在疾病发展中的作用.
科学领域:
- 心脏病学 心脏病学
- 环境健康 环境健康
- 微量元素研究 微量元素研究
背景情况:
- 与膜心脏病 (VHD) 相结合的心房动 (AF) 是一个日益增长的全球健康挑战,具有显著的发病率和死亡率.
- 微量元素度已被涉及到AF的发病,但它们在VHD患者中的作用仍然未被探索.
研究的目的:
- 调查尿液微量元素概况与VHD患者的AF存在之间的关联.
- 探索多个微量元素在这个特定患者群体内对AF风险的联合影响.
主要方法:
- 从144名参与者收集了尿样和临床数据 (72名患有VHD和AF,72名仅患有VHD).
- 分析包括12种微量元素 (,,,铜,,,,,,,,,,,,,,,,,).
- 使用量子g计算来评估微量元素对AF的综合影响,并通过引导重新抽样进行内部验证.
主要成果:
- 与对照组相比,患有VHD和AF的患者表现出尿路 (Sr) 降低和 (Mn),铜 (Cu) 和 (Hg) 水平升高.
- 量子g计算模型显示,12种尿微量元素的混合物与VHD患者的AF之间存在显著的关联 (调整后OR:2.051;p=0.011).
- 铜和显示出积极的部分影响,而和显示出对AF风险的负面部分影响.
结论:
- 在AF的VHD患者中,尿中铜的升高和的降低水平是突出的发现.
- 假设这些特定的微量元素 (Cu,Sr) 在VHD的背景下在AF的发展或进展中起着重要作用.
- 需要进一步调查以阐明这些微量元素与膜心脏病中AF相关的因果机制.
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