在接受塞特拉林治疗的患者中,Bromfed DM诱导的血清激素综合征
John K Jung1, Ismail Zazay1, James R Burmeister2
1John Sealy School of Medicine, University of Texas Medical Branch, Galveston, TX, USA.
SAGE open medical case reports
|November 24, 2025
概括
含有德克斯特罗梅索芬的普通感冒药物增加了血清激素综合征 (SS) 的风险. 一名接受塞特拉林治疗的患者在服用Bromfed DM后出现了SS,这凸显了需要提高意识的必要性.
科学领域:
- 神经科学是一个神经科学.
- 临床药理学 临床药理学
- 毒理学 毒理学 毒理学
背景情况:
- 血清激素综合征 (SS) 是一种严重的疾病,由过度的中枢神经系统血清激素活性引起.
- 虽然经常与药物相互作用有关,但含有德克斯特罗梅索芬 (DM) 或抗胰岛素的非处方 (OTC) 药物也可能导致SS风险.
- 选择性血红素再吸收抑制剂 (SSRI) 经常被处方,增加患者对血红素过载的脆弱性.
研究的目的:
- 在服用塞特拉林和OTC咳药的患者中报告一种血清激素综合征 (SS) 病例.
- 强调普通感冒药物可能触发SS,即使在治疗剂量.
- 强调在出现SS症状的患者中考虑包括OTC药物在内的所有血清激素药物的重要性.
主要方法:
- 一个52岁的男性患者的病例报告.
- 药物病史分析,包括塞特拉林和Bromfed DM (含有非尼拉胺,伪埃弗德林和德克斯特罗梅索芬).
- 临床观察症状和药物停止后的反应.
主要成果:
- 患者接受了塞特拉林治疗,在开始使用Bromfed DM后,患上了SS症状,包括混乱,肌和言语困难.
- 症状在停止使用塞特拉林和Bromfed DM时消失.
- 该案例说明SS可以发生在治疗剂量的相互作用药物.
结论:
- 含有德克斯特罗梅索芬的常见感冒药物在使用SSRI的患者中具有诱导血清激素综合征的重大风险.
- 医疗保健提供者必须在评估包括OTC产品在内的所有药物的血清性潜力时保持警.
- 及时识别和撤销致病剂对于管理血清素综合征和预防严重后果至关重要.
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