系统治疗前转移的部位会影响第四阶段黑色素瘤患者的进展模式和存活率
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I A Vergara1,2,3, S N Lo1,2, I Li1,2
1Melanoma Institute Australia, The University of Sydney, Sydney, Australia.
Immuno-oncology technology
|November 24, 2025
概括
基线转移部位显著影响黑色素瘤治疗结果. 在诊断时的大脑转移预测了接受免疫检查点抑制剂 (ICI) 或BRAF/MEK抑制剂 (BRAF/MEKi) 的患者的无进展生存期 (PFS) 更差,大脑进展更快.
科学领域:
- 在瘤学瘤学.
- 黑色素瘤研究 黑色素瘤研究
- 癌症转移 癌症转移
背景情况:
- 黑色素瘤中的转移部位会影响免疫检查点抑制剂 (ICI) 的反应率和整体存活率.
- 了解初始转移位置如何影响治疗结果对于个性化治疗至关重要.
研究的目的:
- 研究基线转移部位对接受一线ICI或BRAF/MEK抑制剂 (BRAF/MEKi) 的黑色素瘤患者的进展模式和存活率的影响.
主要方法:
- 一种新的图形表示法被用于在347名ICI治疗和210名BRAF/MEKi治疗患者中按时间顺序捕捉转移部位的存在和病变数量.
- 评估了基线转移部位,进展模式和无进展生存期 (PFS) 之间的关联.
主要成果:
- 基线脑转移的患者与没有 (21-32%) 患者相比,表现出更高的脑进展率 (61-67%).
- 基线时的大脑转移与一线ICI患者的PFS恶化有关 (HR1.9,P<0.01).
- 较高的基线脑病变数量与明显更糟糕的1年PFS相关.
结论:
- 基线转移部位,治疗类型 (ICI或BRAF/MEKi) 和抵抗机制共同调节晚期黑色素瘤的进展和存活率.
- 在基线时大脑转移的存在和负担是关键的预后因素.
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